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Genetic drivers of hippocampal atrophy highlight the role of<i>APOE</i>functional variants and AD polygenicity in Mild Cognitive Impairment

2025-03-26

Abstract excerpt

The hippocampus, crucial in cognitive aging and Alzheimer’s disease (AD), shows early atrophy during disease progression. This study investigates 5-year trajectories of hippocampal volumes across AD stages, focusing on genetic predisposition to AD and their impact on hippocampal atrophy. Analyzing data from 1,051 participants in the ADNI, we found that higher genetic predisposition to AD accelerates hippocampal at...

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Literature Corpus work
d050b412-0624-51d5-b780-a03e5005fb77
DOI
10.1101/2025.03.25.25324619
Open publication

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Genetic drivers of hippocampal atrophy highlight the role of<i>APOE</i>functional variants and AD polygenicity in Mild Cognitive ImpairmentDOI 10.1101/2025.03.25.25324619
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