Article

Compositional structural brain signatures capture Alzheimer’s genetic risk on brain structure along the disease<i>continuum</i>

2024-05-08

Abstract excerpt

<h4>INTRODUCTION</h4> Traditional brain imaging genetics studies have primarily focused on how genetic factors influence the volume of specific brain regions, often neglecting the overall complexity of brain architecture and its genetic underpinnings. <h4>METHODS</h4> This study analyzed data from participants across the Alzheimer’s disease (AD) continuum from the ALFA and ADNI studies. We exploited compositional...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9077479f-9da5-5ab0-9270-34b0dcc7dda9
DOI: 10.1101/2024.05.08.24307046

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Compositional structural brain signatures capture Alzheimer’s genetic risk on brain structure along the disease<i>continuum</i>DOI 10.1101/2024.05.08.24307046Read

Polygenic risk for Alzheimer's disease in healthy aging: age-related and APOE-driven effects on brain structures and cognition.Semantic proximity Read

Genetic drivers of hippocampal atrophy highlight the role of<i>APOE</i>functional variants and AD polygenicity in Mild Cognitive ImpairmentSemantic proximity Read

Association between polygenic risk for Alzheimer’s disease, brain structure and cognitive abilities in UK Biobank.Semantic proximity Read

APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia.Semantic proximity Read

Genetic risk for Alzheimer’s disease predicts hippocampal volume through the lifespanSemantic proximity Read

Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers.Semantic proximity Read

Neuroimaging PheWAS and molecular phenotyping implicate <i>PSMC3</i> in Alzheimer’s DiseaseSemantic proximity Read

Genetics impact risk of Alzheimer's disease through mechanisms modulating structural brain morphology in late life.Semantic proximity Read

Causal relationships between neuroimaging phenotypes and the risk of early and late-onset alzheimer's disease.Semantic proximity Read

Incorporating Multi-threshold Polygenic Risk in Hippocampal-based Normative Models Improves Cognitive Decline PredictionSemantic proximity Read

Ancestry-specific effects of <i>APOE</i> on Alzheimer Disease EndophenotypesSemantic proximity Read