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Age-dependent effect of APOE and polygenic component on Alzheimer's disease

29 Apr 2020

Abstract excerpt

Alzheimer's disease (AD) is a devastating neurodegenerative condition with significant genetic heritability. Several genes have been implicated in the onset of AD with the apolipoprotein E (APOE) gene being the strongest single genetic risk loci. Evidence suggests that the effect of APOE alters with age during disease progression. Here, we aim to investigate the impact of APOE and other variants outside the APOE...

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PMID: 32464432
DOI: 10.1016/j.neurobiolaging.2020.04.024

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