Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment.

doi:10.1016/j.jalz.2016.01.006

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Article

Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2016

Louwersheimer Eva, Wolfsgruber Steffen, Espinosa Ana, Lacour André, Heilmann-Heimbach Stefanie, Alegret Montserrat, Hernández Isabel, Rosende-Roca Maitée, Tárraga Lluís, Boada Mercè, Kornhuber Johannes, Peters Oliver, Frölich Lutz, Hüll Michael, Rüther Eckart, Wiltfang Jens, Scherer Martin, Riedel-Heller Steffi, Jessen Frank, Nöthen Markus M, Maier Wolfgang, Koene Ted, Scheltens Philip, Holstege Henne, Wagner Michael, Ruiz Agustín, van der Flier Wiesje M, Becker Tim, Ramirez Alfredo

Abstract excerpt

INTRODUCTION: We evaluated the effect of Alzheimer's disease (AD) susceptibility loci on endophenotypes closely related with AD pathology in patients with mild cognitive impairment (MCI). METHODS: We selected 1730 MCI patients from four independent data sets. Weighted polygenic risk scores (PGS) were constructed of 18 non-apolipoprotein E (APOE) AD risk variants. In addition, we determined APOE genotype. AD...

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PMID: 26921674
DOI: 10.1016/j.jalz.2016.01.006

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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