Article

The impact of APOE ε4 in Alzheimer’s disease: a meta-analysis of voxel-based morphometry studies

2024-05-10

Abstract excerpt

<h4>Background</h4> Alzheimer’s disease (AD) is the most prevalent form of dementia, exerting substantial personal and societal impacts. The apolipoprotein E (APOE) ε4 allele is a known genetic factor that increases the risk of AD, contributing to more severe brain atrophy and exacerbated symptoms. <h4>Purpose</h4> We aim to provide a comprehensive review of the impacts of the APOE ε4 allele on brain atrophy in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2e91145a-e932-533b-84ee-1f9e557150ac
DOI: 10.1101/2024.05.10.24307165

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The impact of APOE ε4 in Alzheimer’s disease: a meta-analysis of voxel-based morphometry studiesDOI 10.1101/2024.05.10.24307165Read

APOE ε4 is associated with disproportionate progressive hippocampal atrophy in AD.Semantic proximity Read

APOE <i>ε</i> 4-Associated Hippocampal Atrophy Trajectories Across the Alzheimer’s Disease Continuum: A Systematic Review, Meta-Analysis, and Longitudinal ValidationSemantic proximity Read

Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study.Semantic proximity Read

Hippocampal volumes in UK Biobank are associated with APOE only in older adultsSemantic proximity Read

Differences in AD-related pathology profiles across APOE groupsSemantic proximity Read

Association Between Hippocampus, Thalamus, and Caudate in Mild Cognitive Impairment APOEε4 Carriers: A Structural Covariance MRI StudySemantic proximity Read

Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network.Semantic proximity Read

Effect of APOE4 Allele and Gender on the Rate of Atrophy in the Hippocampus, Entorhinal Cortex, and Fusiform Gyrus in Alzheimer's Disease.Semantic proximity Read

Apolipoprotein E genotype and MRI-detected brain alterations pertaining to neurodegeneration: A systematic reviewSemantic proximity Read

Effects of APOE-ε4 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer's disease.Semantic proximity Read

Nonlinear cerebral atrophy patterns across the Alzheimer's disease continuum: impact of APOE4 genotype.Semantic proximity Read

APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individualsSemantic proximity Read