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The selective vulnerability of the left fimbria in cognitively normal APOE ε4 carriers: a localized structural correlate of high genetic risk for Alzheimer's disease.

Behavioural brain research - 13 Sept 2026

Suo Yihan, Wang Luoyu, Zhao Yuanyuan, Wen Qingqing, Feng Qi, Zhang Han, Ding Zhongxiang

Abstract excerpt

The apolipoprotein E ε4 (APOE ε4) allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), yet the earliest structural brain alterations associated with ε4 risk remain insufficiently characterized. Here, we utilized a discovery-validation framework to investigate whether cognitively normal APOE ε4 carriers exhibit selective hippocampal subfield alterations and evaluated their...

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Source

Identifiers

PMID: 42297216
DOI: 10.1016/j.bbr.2026.116336

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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