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Article

Polygenic risk for Alzheimer's disease in healthy aging: age-related and APOE-driven effects on brain structures and cognition.

Genome medicine - 21 Oct 2025

Chen Hao-Jie, Dong Xinyi, Wang Yichen, Wang Kexin, Feng Guozheng, Bai Tianyu, Zhang Mingkai, Gan Kaiyu, Peng Jun-Jie, Huang Weijie, Zhang Zhanjun, Shu Ni, Ma Guolin

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is characterized by progressive neurodegeneration and cognitive decline with age. The genetic architecture of AD involves multiple loci, including the apolipoprotein E gene (APOE). The polygenic risk scores for AD (AD-PRS) provide a comprehensive genome-wide assessment of AD risk, yet their age-related effects on brain structures and cognitive function in cognitively...

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Identifiers

PMID: 41121378
DOI: 10.1186/s13073-025-01548-z
PMCID: PMC12539216

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APOE

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