Article

AURKB-driven dissolution of CIZ1-RNA assemblies from the inactive X chromosome in mitosis

2025-09-20

Abstract excerpt

Cip1-interacting zinc-finger protein 1 (CIZ1) interacts with Xist lncRNA to form large RNA-protein assemblies at the inactive X-chromosome (Xi) in female mammalian nuclei, plus smaller assemblies in both sexes. CIZ1 assemblies influence underlying chromatin, and their disruption alters the expression of autosomal and X-linked gene clusters. Here, we explore the regulated dissolution of CIZ1-Xi assemblies during m...

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Literature Corpus work: cf8ae0b5-25e1-57a5-9a01-cc3dd11129e6
DOI: 10.1101/2025.09.17.676856

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