Article

Epigenetic deprogramming driven by disruption of CIZ1-RNA nuclear assemblies in early-stage breast cancers

2024-08-22

Abstract excerpt

CIZ1 is part of the large RNA-dependent supramolecular assemblies that form around the inactive X-chromosome (Xi) in female cells, and smaller assemblies throughout the nucleus in males and females. Here we show that CIZ1 C-terminal anchor domain (AD) is elevated in primary human breast tumour transcriptomes, even at stage I. Elevation of AD correlates with deprotection of chromatin, and up-regulation of lncRNA-co...

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Literature Corpus work: a880f95f-c024-57d0-ab00-0f617a75172c
DOI: 10.1101/2024.08.22.609161

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