Article

The CRL4B E3 ligase regulates mitosis by recruiting phospho-specific DCAFs

2022-10-14

Abstract excerpt

The cullin-4 paralogs CUL4A and CUL4B assemble E3 ubiquitin ligase complexes regulating multiple chromatin-associated cellular functions. Although they are structurally similar, we found that the unique N-terminal extension of CUL4B is heavily phosphorylated during mitosis, and the phosphorylation pattern is perturbed in the CUL4B-P50L mutation causing X-linked intellectual disability (XLID). Phenotypic characteri...

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Literature Corpus work: 25f6c21a-8f6c-5348-b322-d97a2aa936ff
DOI: 10.1101/2022.10.14.512051

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