Article

Dominant CIZ1 fragments drive epigenetic instability and are expressed in early stage cancers

2023-09-22

Abstract excerpt

CIZ1 is a nuclear matrix protein that is part of the large RNA-dependent supramolecular assembly complexes (SMACs) that form at the inactive X chromosome (Xi) in female cells, and smaller assemblies throughout the nucleus in males and females. It plays a role in maintenance of epigenetic state and gene expression in differentiated cells, via stabilisation of histone post-translational modifications H2AK119ub1 and...

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Literature Corpus work: 22f53a5e-f792-5b08-8fd0-bb947ea0ebff
DOI: 10.1101/2023.09.22.558821

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