AGO1 in association with <i>NEAT1</i> lncRNA contributes to nuclear and 3D chromatin architecture in human cells

Abstract excerpt

Aside from their roles in the cytoplasm, RNA-interference components have been reported to localize also in the nucleus of human cells. In particular, AGO1 associates with active chromatin and appears to influence global gene expression. However, the mechanistic aspects remain elusive. Here, we identify AGO1 as a paraspeckle component that in combination with the NEAT1 lncRNA maintains 3D genome architecture. We...

Topics

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• Catalytic Domain
• Chromatin
• Chromosomal Proteins, Non-Histone
• Clustered Regularly Interspaced Short Palindromic Repeats
• In Situ Hybridization, Fluorescence
• NIH 3T3 Cells
• RNA, Long Noncoding
• RNA, Untranslated

Identifiers and source

Literature Corpus work

eab42e49-d2e1-5f29-bb49-1e5cc3673d7b

DOI

10.1101/525527