Article

Rio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores.

2021-12-29

Abstract excerpt

<title>Abstract</title> <p>Kinetochores assemble on centromeres (CENs) via histone H3 variant CENP-A and low levels of CEN transcripts. RNA polymerase II (RNAPII) activity is restrained by the CEN histone code, while CEN RNA concentrations are reduced by the nuclear exosome. Using S. cerevisiae, we add kinase Rio1 to this scheme as it downregulates RNAPII, and promotes CEN RNA turnover via exoribonuclease Rat1. T...

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Literature Corpus work: 67242683-4178-507e-857b-f218edcf9d18
DOI: 10.21203/rs.3.rs-1132116/v1

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