Article

BHLHE40/41 regulate macrophage/microglia responses associated with Alzheimer’s disease and other disorders of lipid-rich tissues

2023-02-13

Abstract excerpt

<h4>Background</h4> Genetic and experimental evidence strongly implicates myeloid cells in the etiology of AD and suggests that AD-associated alleles and genes may modulate disease risk by altering the transcriptional and cellular responses of macrophages (like microglia) to damage of lipid-rich tissues (like the brain). Specifically, recent single-cell/nucleus RNA sequencing (sc/nRNA-seq) studies identified a tr...

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Literature Corpus work: 5123bb8b-1d56-5c00-a932-60ae41582753
DOI: 10.1101/2023.02.13.528372

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