Article

Divergence in dimerization and activity of primate APOBEC3C

2021-07-13

Abstract excerpt

The APOBEC3 (A3) family of single-stranded DNA cytidine deaminases are host restriction factors that inhibit lentiviruses, such as HIV-1, in the absence of the Vif protein that causes their degradation. Deamination of cytidine in HIV-1 (-)DNA forms uracil that causes inactivating mutations when uracil is used as a template for (+)DNA synthesis. For APOBEC3C (A3C), the chimpanzee and gorilla orthologues are more ac...

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Identifiers and source

Literature Corpus work: cf51198b-bc6a-5ca5-ad68-97b09d658092
DOI: 10.1101/2021.07.13.452235

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