Article

Recurrent Loss of APOBEC3H Activity during Primate Evolution

2018-05-01

Abstract excerpt

Genes in the APOBEC3 family encode cytidine deaminases that provide a barrier against viral infection and retrotransposition. Of all APOBEC3 genes in humans, APOBEC3H (A3H) is the most polymorphic: some haplotypes encode stable and active A3H proteins, while others are unstable and inactive. Such variation in human A3H affects interactions with the lentiviral antagonist Vif, which counteracts A3H via proteasoma...

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Literature Corpus work: 97970220-152c-5e79-8d33-ffc1b9586a51
DOI: 10.1101/311878

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