Article

HIV-1 Vif gained breadth in APOBEC3G specificity after cross-species transmission of its precursors

2021-08-23

Abstract excerpt

APOBEC3G (A3G) is a host-encoded cytidine deaminase that potently restricts retroviruses, such as HIV-1, and depends on its ability to package into virions. As a consequence of this, HIV-1 protein Vif has evolved to antagonize human A3G by targeting it for ubiquitination and subsequent degradation. There is an ancient arms-race between Vif and A3G highlighted by amino acids 128 and 130 in A3G that have evolved und...

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Literature Corpus work: 6ff80feb-7c43-55a3-899e-86f3523ab903
DOI: 10.1101/2021.08.23.457421

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