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Article

Antiretroelement activity of APOBEC3H was lost twice in recent human evolution.

Cell host & microbe - 11 Sept 2008

OhAinle Molly, Kerns Julie A, Li Melody M H, Malik Harmit S, Emerman Michael

Abstract excerpt

The primate APOBEC3 gene locus encodes a family of proteins (APOBEC3A-H) with various antiviral and antiretroelement activities. Here, we trace the evolution of APOBEC3H activity in hominoids to identify a human-specific loss of APOBEC3H antiviral activity. Reconstruction of the predicted ancestral human APOBEC3H protein shows that human ancestors encoded a stable form of this protein with potent antiviral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18779051
DOI: 10.1016/j.chom.2008.07.005
PMCID: PMC2608726

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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