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Article

Human Cytidine Deaminase APOBEC3H Restricts HIV-1 Replication

25 Feb 2008

Abstract excerpt

The human genome encodes seven APOBEC3 (A3) cytidine deaminases with potential antiretroviral activity: A3A, A3B, A3C, A3DE, A3F, A3G, and A3H. A3G was the first identified to block replication of human immunodeficiency virus type 1 (HIV-1) and many other retroviruses. A3F, A3B, and A3DE were shown later to have similar activities. HIV-1 produces a protein called Vif that is able to neutralize the antiretroviral...

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Identifiers

PMID: 18299330
DOI: 10.1074/jbc.m707586200

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