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Article

Divergence in Dimerization and Activity of Primate APOBEC3C.

Journal of molecular biology - 3 Dec 2021

Gaba Amit, Hix Mark A, Suhail Sana, Flath Ben, Boysan Brock, Williams Danielle R, Pelletier Tomas, Emerman Michael, Morcos Faruck, Cisneros G Andrés, Chelico Linda

Abstract excerpt

The APOBEC3 (A3) family of single-stranded DNA cytidine deaminases are host restriction factors that inhibit lentiviruses, such as HIV-1, in the absence of the Vif protein that causes their degradation. Deamination of cytidine in HIV-1 (-)DNA forms uracil that causes inactivating mutations when uracil is used as a template for (+)DNA synthesis. For APOBEC3C (A3C), the chimpanzee and gorilla orthologues are more...

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Identifiers

PMID: 34666043
DOI: 10.1016/j.jmb.2021.167306
PMCID: PMC9202443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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