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Article

Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.

PLoS biology - 1 Sept 2004

Sawyer Sara L, Emerman Michael, Malik Harmit S

Abstract excerpt

Host genomes have adopted several strategies to curb the proliferation of transposable elements and viruses. A recently discovered novel primate defense against retroviral infection involves a single-stranded DNA-editing enzyme, APOBEC3G, that causes hypermutation of HIV. The HIV-encoded virion infectivity factor (Vif) protein targets APOBEC3G for destruction, setting up a genetic conflict between the APOBEC3G...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15269786
DOI: 10.1371/journal.pbio.0020275
PMCID: PMC479043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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