Article

Loop 1 of APOBEC3C regulates its antiviral activity against HIV-1

2020-02-06

Abstract excerpt

<h4>ABSTRACT</h4> APOBEC3 deaminases (A3s) provide mammals with an anti-retroviral barrier by catalyzing dC-to-dU deamination on viral ssDNA. Within primates, A3s have evolved diversely via gene duplications and fusions. Human APOBEC3C (hA3C) efficiently restricts the replication of viral infectivity factor ( vif )-deficient Simian immunodeficiency virus (SIVΔ vif ), but for unknown reasons, it inhibits HIV-1...

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Identifiers and source

Literature Corpus work: 3cdc111a-162b-57b8-8dfc-956ab854f91d
DOI: 10.1101/2020.02.05.936021

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