Article
Ion channel depolarization increases repulsions between positive S4 charges to drive activation
2019-07-03
Abstract excerpt
The positively charged residues, arginine and lysine, of the S4 segments of voltage-sensitive ion channels repel each other with Coulomb forces inversely proportional to the mean channel dielectric permittivity ε. Dipole moments induced at rest potential in the branched sidechains of leucine, isoleucine and valine lend high values of ε to the channel. High ε keeps electrostatic forces small at rest, leaving the ch...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- ced4d0f9-17b9-5ef6-8887-14a7db513f10
- DOI
- 10.1101/691881