Article
Gating charge interactions with the S1 segment during activation of a Na+ channel voltage sensor.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 2011
DeCaen Paul G, Yarov-Yarovoy Vladimir, Scheuer Todd, Catterall William A
Abstract excerpt
Voltage-gated Na(+) channels initiate action potentials during electrical signaling in excitable cells. Opening and closing of the pore of voltage-gated ion channels are mechanically linked to voltage-driven outward movement of the positively charged S4 transmembrane segment in their voltage sensors. Disulfide locking of cysteine residues substituted for the outermost T0 and R1 gating-charge positions and a...
Topics
- Cell Line
- Cysteine
- Disulfides
- Electrochemistry
- Humans
- Ion Channel Gating
- Ions
- Kinetics
- Mutation
- Patch-Clamp Techniques
- Protein Binding
- Protein Conformation
- Signal Transduction
- Sodium
- Sodium Channels
- Time Factors