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Article

Mechanism of voltage sensing in Ca2+- and voltage-activated K+ (BK) channels.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 2022

Carrasquel-Ursulaez Willy, Segura Ignacio, Díaz-Franulic Ignacio, Echeverría Felipe, Lorenzo-Ceballos Yenisleidy, Espinoza Nicolás, Rojas Maximiliano, Garate Jose Antonio, Perozo Eduardo, Alvarez Osvaldo, Gonzalez-Nilo Fernando D, Latorre Ramón

Abstract excerpt

In neurosecretion, allosteric communication between voltage sensors and Ca2+ binding in BK channels is crucially involved in damping excitatory stimuli. Nevertheless, the voltage-sensing mechanism of BK channels is still under debate. Here, based on gating current measurements, we demonstrate that two arginines in the transmembrane segment S4 (R210 and R213) function as the BK gating charges. Significantly, the...

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Identifiers

PMID: 35704760
DOI: 10.1073/pnas.2204620119
PMCID: PMC9231616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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