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Article

Role of hydrophobic and ionic forces in the movement of S4 of the Shaker potassium channel.

Molecular membrane biology - 1 Dec 2012

Elliott David J S, Neale Edward J, Munsey Tim S, Bannister John P, Sivaprasadarao Asipu

Abstract excerpt

Voltage-gated ion (K(+), Na(+), Ca(2+)) channels contain a pore domain (PD) surrounded by four voltage sensing domains (VSD). Each VSD is made up of four transmembrane helices, S1-S4. S4 contains 6-7 positively charged residues (arginine/lysine) separated two hydrophobic residues, whereas S1-S3 contribute to two negatively charged clusters. These structures are conserved among all members of the voltage-gated ion...

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Identifiers

PMID: 22881396
DOI: 10.3109/09687688.2012.710343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of hydrophobic and ionic forces in the movement of S4 of the Shaker potassium channel.PMID 22881396Read ↗

Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels.Semantic proximity Read ↗

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Transmembrane movement of the shaker K+ channel S4.Semantic proximity Read ↗

Nonsensing residues in S3-S4 linker's C terminus affect the voltage sensor set point in K+ channels.Semantic proximity Read ↗

Localization of the extracellular end of the voltage sensor S4 in a potassium channel.Semantic proximity Read ↗

Atomic proximity between S4 segment and pore domain in Shaker potassium channels.Semantic proximity Read ↗

S4 mutations alter the single-channel gating kinetics of Shaker K+ channels.Semantic proximity Read ↗

Initial steps in the opening of a Shaker potassium channel.Semantic proximity Read ↗

Gating of shaker-type channels requires the flexibility of S6 caused by prolines.Semantic proximity Read ↗

The conserved phenylalanine in the K+ channel voltage-sensor domain creates a barrier with unidirectional effects.Semantic proximity Read ↗

Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel.Semantic proximity Read ↗

Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.Semantic proximity Read ↗

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