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Article

Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation.

Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2008

DeCaen Paul G, Yarov-Yarovoy Vladimir, Zhao Yong, Scheuer Todd, Catterall William A

Abstract excerpt

The S4 transmembrane segments of voltage-gated ion channels move outward on depolarization, initiating a conformational change that opens the pore, but the mechanism of S4 movement is unresolved. One structural model predicts sequential formation of ion pairs between the S4 gating charges and negative charges in neighboring S2 and S3 transmembrane segments during gating. Here, we show that paired cysteine...

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Identifiers

PMID: 18809926
DOI: 10.1073/pnas.0806486105
PMCID: PMC2567506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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