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Article

Beta-scorpion toxin effects suggest electrostatic interactions in domain II of voltage-dependent sodium channels.

The Journal of physiology - 1 Oct 2005

Mantegazza Massimo, Cestèle Sandrine

Abstract excerpt

Beta-scorpion toxins specifically modulate the voltage dependence of sodium channel activation by acting through a voltage-sensor trapping model. We used mutagenesis, functional analysis and the action of beta-toxin as tools to investigate the existence and role in channel activation of molecular interactions between the charged residues of the S2, S3 and S4 segments in domain II of sodium channels. Mutating to...

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Identifiers

PMID: 16020455
DOI: 10.1113/jphysiol.2005.093484
PMCID: PMC1474769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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