Article
S1-S3 counter charges in the voltage sensor module of a mammalian sodium channel regulate fast inactivation.
The Journal of general physiology - 1 May 2013
Groome James R, Winston Vern
Abstract excerpt
The movement of positively charged S4 segments through the electric field drives the voltage-dependent gating of ion channels. Studies of prokaryotic sodium channels provide a mechanistic view of activation facilitated by electrostatic interactions of negatively charged residues in S1 and S2 segments, with positive counterparts in the S4 segment. In mammalian sodium channels, S4 segments promote domain-specific...
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