Article
State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation.
The Journal of general physiology - 1 Jun 2010
Wu Dick, Delaloye Kelli, Zaydman Mark A, Nekouzadeh Ali, Rudy Yoram, Cui Jianmin
Abstract excerpt
The voltage-sensing domain of voltage-gated channels is comprised of four transmembrane helices (S1-S4), with conserved positively charged residues in S4 moving across the membrane in response to changes in transmembrane voltage. Although it has been shown that positive charges in S4 interact with negative countercharges in S2 and S3 to facilitate protein maturation, how these electrostatic interactions...
Topics
- Amino Acid Sequence
- Animals
- Arginine
- Cell Membrane
- Cysteine
- Ion Channel Gating
- KCNQ1 Potassium Channel
- Long QT Syndrome
- Membrane Potentials
- Mesylates
- Models, Molecular