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Article

Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP.

The Journal of general physiology - 1 Jan 2024

Shen Rong, Roux Benoît, Perozo Eduardo

Abstract excerpt

The S4 segment of voltage-sensing domains (VSDs) directly responds to voltage changes by reorienting within the electric field as a permion. A narrow hydrophobic "gasket" or charge transfer center at the core of most VSDs focuses the electric field into a narrow region and catalyzes the sequential and reversible translocation of S4 positive gating charge residues across the electric field while preventing the...

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Identifiers

PMID: 38019193
DOI: 10.1085/jgp.202213311
PMCID: PMC10686229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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