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Article

Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP.

The Journal of general physiology - 1 Jan 2024

Shen Rong, Roux Benoît, Perozo Eduardo

Abstract excerpt

The S4 segment of voltage-sensing domains (VSDs) directly responds to voltage changes by reorienting within the electric field as a permion. A narrow hydrophobic "gasket" or charge transfer center at the core of most VSDs focuses the electric field into a narrow region and catalyzes the sequential and reversible translocation of S4 positive gating charge residues across the electric field while preventing the...

Topics

Animals
Ciona intestinalis
Electricity
Ion Transport
Mutation
Phosphoric Monoester Hydrolases

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38019193
DOI: 10.1085/jgp.202213311
PMCID: PMC10686229

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