Article
Initial steps in the opening of a Shaker potassium channel.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jul 2012
Hoshi Toshinori, Armstrong Clay M
Abstract excerpt
The structural model of a K(V) (K(+)-selective, voltage-gated) channel in the open state is known (Protein Data Bank ID code 2R9R). Each subunit of the channel has four negatively charged residues distributed in the transmembrane segments S1, S2, and S3 that bind to and facilitate the movement within the membrane of the positively charged, voltage-sensing residues of S4. When extrapolated to the closed state, the...
Topics
- Animals
- Cell Line, Tumor
- HEK293 Cells
- Humans
- Ion Channel Gating
- Lanthanum
- Membrane Potentials
- Mice
- Mutation
- Protein Structure, Quaternary
- Protein Structure, Tertiary