Article

Leucine Rich Repeat Kinase 2 is not required for lysozyme expression in intestinal Paneth cells

2024-03-08

Abstract excerpt

Genetic variants in Leucine-rich Repeat Kinase 2 ( LRRK2) gene have been linked to Parkinson’s disease (PD) and are also associated with inflammatory bowel diseases (IBD), specifically Crohn’s disease (CD), a transmural inflammation that can affect the entire length of the gastrointestinal tract and is commonly seen in the ileum 1 . In ileal CD, defects in specialized intestinal epithelial cells known as Paneth...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ce40f63c-e48f-5672-b187-d93b0af58df9
DOI: 10.1101/2024.03.07.582590

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leucine Rich Repeat Kinase 2 is not required for lysozyme expression in intestinal Paneth cellsDOI 10.1101/2024.03.07.582590Read

Secretory autophagy of lysozyme in Paneth cells.Semantic proximity Read

Paneth Cell Alterations in the Development and Phenotype of Crohn's Disease.Semantic proximity Read

LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients.Semantic proximity Read

LRRK2 Is Involved in the IFN-γ Response and Host Response to PathogensSemantic proximity Read

Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine.Semantic proximity Read

Regulation of Leucine-Rich Repeat Kinase 2 by inflammation and IL-4Semantic proximity Read

Inflammation and IL-4 regulate Parkinson's and Crohn's disease associated kinase LRRK2.Semantic proximity Read

A common role for Atg16L1, Atg5, and Atg7 in small intestinal Paneth cells and Crohn diseaseSemantic proximity Read

LRRK2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitisSemantic proximity Read

Paneth's disease.Semantic proximity Read

Lack of Intestinal Epithelial Atg7 Affects Paneth Cell Granule Formation but Does Not Compromise Immune Homeostasis in the GutSemantic proximity Read

The role of autophagy in Paneth cell differentiation and secretion.Semantic proximity Read