Article
Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine.
Science (New York, N.Y.) - 8 Sept 2017
Bel Shai, Pendse Mihir, Wang Yuhao, Li Yun, Ruhn Kelly A, Hassell Brian, Leal Tess, Winter Sebastian E, Xavier Ramnik J, Hooper Lora V
Abstract excerpt
Intestinal Paneth cells limit bacterial invasion by secreting antimicrobial proteins, including lysozyme. However, invasive pathogens can disrupt the Golgi apparatus, interfering with secretion and compromising intestinal antimicrobial defense. Here we show that during bacterial infection, lysozyme is rerouted via secretory autophagy, an autophagy-based alternative secretion pathway. Secretory autophagy was...
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