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Article

Paneth's disease.

Journal of Crohn's & colitis - 1 Nov 2010

Wehkamp Jan, Stange Eduard F

Abstract excerpt

In about 70% of patients Crohn's disease (CD) affects the small intestine. This disease location is stable over time and associated with a genetic background different from isolated colonic disease. A characteristic feature of small intestinal host defense is the presence of Paneth cells at the bottom of the crypts of Lieberkühn. These cells produce different broad spectrum antimicrobial peptides (AMPs) most...

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Source

Identifiers

PMID: 21122555
DOI: 10.1016/j.crohns.2010.05.010

Genes

DEFA5
DEFA6
KCNN4
NOD2
TCF4
TLR9
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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