Article

Regulation of Leucine-Rich Repeat Kinase 2 by inflammation and IL-4

2024-05-02

Abstract excerpt

<h4>Summary</h4> Mutations in Leucine-Rich Repeat protein Kinase 2 (LRRK2) are associated with Parkinson’s Disease (PD) and Crohn’s Disease (CD), but the regulation of LRRK2 during inflammation remains relatively unexplored. Here we developed a flow cytometry-based assay to assess LRRK2 activity in individual cells and created an EGFP-Lrrk2-knock-in reporter mouse to analyse cell-specific LRRK2 expression. Using...

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Literature Corpus work: f628d3ae-134a-5814-bc11-9a6beab0b4d1
DOI: 10.1101/2024.04.29.591170

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