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Article

A common role for Atg16L1, Atg5, and Atg7 in small intestinal Paneth cells and Crohn disease

16 Feb 2009

Abstract excerpt

Recently identified genetic determinants for enhanced susceptibility to Crohn disease (CD) included polymorphisms in the ATG16L1 and IRGM1 loci suggesting that the autophagy pathway plays a role in the pathogenesis of this disease. We have generated and analyzed three mouse models with diminished expression of autophagy proteins and show how the loss of function of various autophagy components contributes to CD...

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PMID: 19139628
DOI: 10.4161/auto.5.2.7560

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