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LRRK2 Is Involved in the IFN-γ Response and Host Response to Pathogens

5 Oct 2010

Abstract excerpt

LRRK2 was previously identified as a defective gene in Parkinson's disease, and it is also located in a risk region for Crohn's disease. In this study, we aim to determine whether LRRK2 could be involved in immune responses. We show that LRRK2 expression is enriched in human immune cells. LRRK2 is an IFN-γ target gene, and its expression increased in intestinal tissues upon Crohn's disease inflammation. In...

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PMID: 20921534
DOI: 10.4049/jimmunol.1000548

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