Article
LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients.
JCI insight - 23 Mar 2017
Liu Ta-Chiang, Naito Takeo, Liu Zhenqiu, VanDussen Kelli L, Haritunians Talin, Li Dalin, Endo Katsuya, Kawai Yosuke, Nagasaki Masao, Kinouchi Yoshitaka, McGovern Dermot Pb, Shimosegawa Tooru, Kakuta Yoichi, Stappenbeck Thaddeus S
Abstract excerpt
BACKGROUND. Morphological patterns of Paneth cells are a prognostic biomarker in Western Crohn's disease (CD) patients, and are associated with autophagy-associated ATG16L1 and NOD2 variants. We hypothesized that genetic determinants of Paneth cell phenotype in other ethnic CD cohorts are distinct but also involved in autophagy. METHODS. We performed a hypothesis-driven analysis of 56 single nucleotide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.