Article

LRRK2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis

2024-12-02

Abstract excerpt

Parkinson’s Disease (PD) is a progressive, neurodegenerative disorder characterised by motor and non-motor symptoms. Emerging evidence suggests a link between PD and gastrointestinal dysfunction. Constipation is frequently observed years prior to development of motor dysfunction in PD, and people with inflammatory bowel disease (IBD) are more likely to develop PD. Mutations in the leucine-rich repeat kinase 2 gene...

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Literature Corpus work: bbb0f06c-fcf8-5267-aac0-b6a8d926f9ba
DOI: 10.1101/2024.11.26.625468

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