Article
Inflammation and IL-4 regulate Parkinson's and Crohn's disease associated kinase LRRK2.
EMBO reports - 1 Jul 2025
Dikovskaya Dina, Pemberton Rebecca, Taylor Matthew, Tasegian Anna, Bhattacharya Purbasha, Zeneviciute Karolina, Sammler Esther M, Howden Andrew J M, Alessi Dario R, Swamy Mahima
Abstract excerpt
Mutations in Leucine-Rich Repeat protein Kinase 2 (LRRK2) are associated with Parkinson's disease (PD) and Crohn's disease (CD), but the regulation of LRRK2 during inflammation remains relatively unexplored. Here we describe the development of a flow cytometry-based assay to assess LRRK2 activity in individual cells and the generation of an EGFP-Lrrk2 knock-in reporter mouse to analyse cell-specific LRRK2...
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