Article
Evidence for stabilizing selection at pleiotropic loci for human complex traits
2017-04-12
Abstract excerpt
How genetic variation contributes to phenotypic variation is a central question in genetics. Association signals for a complex trait are found throughout the majority of the genome suggesting much of the genome is under some degree of genetic constraint. Here, we develop a intraspecific population genetics approach to define a measure of population structure for each single nucleotide polymorphism (SNP). Using thi...
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Identifiers and source
- Literature Corpus work
- ce32c8cb-bbc1-54ce-87fb-188818842466
- DOI
- 10.1101/126888