Article
Signatures of negative selection in the genetic architecture of human complex traits.
Nature genetics - 1 May 2018
Zeng Jian, de Vlaming Ronald, Wu Yang, Robinson Matthew R, Lloyd-Jones Luke R, Yengo Loic, Yap Chloe X, Xue Angli, Sidorenko Julia, McRae Allan F, Powell Joseph E, Montgomery Grant W, Metspalu Andres, Esko Tonu, Gibson Greg, Wray Naomi R, Visscher Peter M, Yang Jian
Abstract excerpt
We develop a Bayesian mixed linear model that simultaneously estimates single-nucleotide polymorphism (SNP)-based heritability, polygenicity (proportion of SNPs with nonzero effects), and the relationship between SNP effect size and minor allele frequency for complex traits in conventionally unrelated individuals using genome-wide SNP data. We apply the method to 28 complex traits in the UK Biobank data...
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