Article
Locus-level antagonistic selection shaped the polygenic architecture of human complex diseases.
Human genetics - 1 Dec 2022
Song Weichen, Yuan Kai, Liu Zhe, Cai Wenxiang, Chen Jue, Yu Shunying, Zhao Min, Lin Guan Ning
Abstract excerpt
BACKGROUND: We aimed to evaluate the potential role of antagonistic selection in polygenic diseases: if one variant increases the risk of one disease and decreases the risk of another disease, the signals of genetic risk elimination by natural selection will be distorted, which leads to a higher frequency of risk alleles. METHODS: We applied local genetic correlations and transcriptome-wide association studies to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.