Article

Widespread signatures of negative selection in the genetic architecture of human complex traits

2017-06-03

Abstract excerpt

Estimation of the joint distribution of effect size and minor allele frequency (MAF) for genetic variants is important for understanding the genetic basis of complex trait variation and can be used to detect signature of natural selection. We develop a Bayesian mixed linear model that simultaneously estimates SNP-based heritability, polygenicity (i.e. the proportion of SNPs with nonzero effects) and the relationsh...

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Literature Corpus work: ea3bd9ef-21c9-57a9-9e11-00bc061a5586
DOI: 10.1101/145755

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