Article

Stabilising selection enriches the tails of complex traits with rare alleles of large effect

2024-09-12

Abstract excerpt

Establishing the relative contribution of common and rare variants to complex trait heritability is a key goal of biomedical research. Recent statistical genetics inference suggests that common variants explain most complex trait heritability, but little is known about how genetic architecture varies across the trait continuum. If rare variants make a small contribution to heritability but have their effects conce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 50a47fab-6e07-532f-aa5b-308e51fa42db
DOI: 10.1101/2024.09.12.612687

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Stabilising selection enriches the tails of complex traits with rare alleles of large effectDOI 10.1101/2024.09.12.612687Read

Distinct genetic architecture in the tails of complex traits.Semantic proximity Read

Population genetics of rare variants and complex diseases.Semantic proximity Read

Selection and explosive growth alter genetic architecture and hamper the detection of causal rare variants.Semantic proximity Read

Selection and explosive growth may hamper the performance of rare variant association testsSemantic proximity Read

Striking Departures from Polygenic Architecture in the Tails of Complex TraitsSemantic proximity Read

The impact of population demography and selection on the genetic architecture of complex traits.Semantic proximity Read

Mutation-selection-drift balance models of complex diseasesSemantic proximity Read

Evidence for stabilizing selection at pleiotropic loci for human complex traitsSemantic proximity Read

A Model of Compound Heterozygous, Loss-of-Function Alleles Is Broadly Consistent with Observations from Complex-Disease GWAS Datasets.Semantic proximity Read

Properties and modeling of GWAS when complex disease risk is due to non-complementing, deleterious mutations in genes of large effect.Semantic proximity Read

Heritability of complex traits in sub-populations experiencing bottlenecks and growth.Semantic proximity Read

Signatures of negative selection in the genetic architecture of human complex traits.Semantic proximity Read