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Article

Mosaic patterns of selection in genomic regions associated with diverse human traits.

PLoS genetics - 1 Nov 2022

Abraham Abin, LaBella Abigail L, Capra John A, Rokas Antonis

Abstract excerpt

Natural selection shapes the genetic architecture of many human traits. However, the prevalence of different modes of selection on genomic regions associated with variation in traits remains poorly understood. To address this, we developed an efficient computational framework to calculate positive and negative enrichment of different evolutionary measures among regions associated with complex traits. We applied...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36342969
DOI: 10.1371/journal.pgen.1010494
PMCID: PMC9671423

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