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Leveraging GWAS for complex traits to detect signatures of natural selection in humans.

Current opinion in genetics & development - 1 Dec 2018

Guo Jing, Yang Jian, Visscher Peter M

Abstract excerpt

Natural selection can shape the genetic architecture of complex traits. In human populations, signals of positive selection at genetic loci have been detected through a variety of genome-wide scanning approaches without the knowledge of how genes affect traits or fitness. In the past decade, genome-wide association studies (GWAS) have provided unprecedented insights into the genetic basis of quantitative...

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PMID: 29913353
DOI: 10.1016/j.gde.2018.05.012

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