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Article

Distinct genetic architecture in the tails of complex traits.

Nature - 1 Jul 2026

Souaiaia T, Wu H M, Ori A P S, Choi S W, Hoggart C J, O'Reilly P F

Abstract excerpt

Complex traits are highly polygenic, with heritability explained by many hundreds of common variants of small effect together with rare variants of large effect1. Yet how this genetic architecture varies along the trait continuum has been underexplored, as has the role of natural selection in shaping this variation. Here we developed an approach based on polygenic risk scores that reveals widespread departures...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42203881
DOI: 10.1038/s41586-026-10516-5
PMCID: PMC13372694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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