Article

Endothelial Rho kinase controls blood vessel integrity and angiogenesis

2024-11-19

Abstract excerpt

<h4>Background</h4> The Rho kinases 1 and 2 (ROCK1/2) are serine-threonine specific protein kinases that control actin cytoskeleton dynamics. They are expressed in all cells throughout the body, including cardiomyocytes, smooth muscle cells and endothelial cells, and intimately involved in cardiovascular health and disease. Pharmacological ROCK inhibition is beneficial in mouse models of hypertension, atheroscler...

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Literature Corpus work: cdc71410-dd8f-5c22-ac95-00c6172b33ea
DOI: 10.1101/2024.11.19.624343

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